The goal of our lab is to elucidate the intricate mechanisms regulating the miRNA biogenesis and activity as well as the function of other types of small RNAs. We have currently several ongoing projects studying how the different steps of the miRNA biogenesis are regulated, nuclear function of miRNAs, and the evolution of these small molecules. We are using genetic approaches to identify new proteins regulating the small RNA pathways, and state-of-the-are thechnologies to understand, at molecular level, how they act. We are also focused in understanding how some of the well-known components of the miRNA processing machinery work and how their action are regulated. But we don’t limit our studies only to the biogenesis of miRNAs, we are also interested in the regulation of the miRNA loading into the RISC as well as in the modulation of the activity of this complex. Additionally, we are also interesting in all kind of small RNAs and how they regulate epigenetically the expression of genes and the genome topology.